Epigenome Editing

Reprogramming DNA methylation using CRISPR/Cas9

Welcome! This resource page provides the information and resources needed to implement a CRISPR/Cas9-targeted DNA methyltransferase system for site-specific induction of DNA methylation. This project is a joint collaboration between the Edwards and Challen labs.

We have used the protocols and resources below to induce methylation and decrease gene expression as described in Reprogrammable CRISPR/Cas9-based system for inducing site-specific DNA methylation.

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