We are focused on identifying disease-modifying genetic and epigenetic variants and associated environmental triggers. With this information we will be able to develop individual risk profiles and treatment strategies for common diseases such as heart disease, diabetes, hypertension, obesity and cancer.

Center faculty members are highly interactive and fully integrated within basic and clinical sciences at Washington University. Current areas of research include adrenergic pathways in heart failure, transcriptional regulation of apoptosis, gene interactions with warfarin, epigenetic abnormalities in cancer and cancer progression. Research programs feature strong molecular, cellular and genetic components with an emphasis on organ and whole animal function.



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