Regulation of the EDC
We have previously identified a group of conserved noncoding elements (CNEs) in the EDC that demonstrate dynamic regulatory activity. Two CNEs, 621 and 923, exhibited epidermal-specific enhancer activity in transgenic reporter mice. CNE 621 mapped within a psoriasis copy number variant (LCE3C_LCE3Bdel) suggesting loss of regulatory activity in psoriasis. We are currently investigating a role for CNE923 as a locus control region (LCR) or “master switch” for EDC gene expression using experimental (molecular, biochemical) and bioinformatic approaches.