Human Keratinocyte Epigenome

How does a proliferating epidermal cell (keratinocyte) evolve to a terminally differentiated cell and form the essential unit of the skin barrier? We hypothesize that execution of this biological process relies on the epigenome of the keratinocyte. To address this, we are capturing global epigenetic changes in the different physiological states of the keratinocyte using ChIP-Seq and RNA-Seq coupled with next-generation sequencing.

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