Genetic Studies in Atopic Dermatitis (AD)

Several genetic variants have been identified in the common inflammatory skin disease, atopic dermatitis, including the gene filaggrin, FLG, in the EDC. Linkage to the EDC still persists while excluding FLG. This observation and identification of a tagging SNP on 11q13 suggest additional genetic variants in AD. We hypothesize that causal variants reside near these tagging SNPs. We are currently investigating additional variants using targeted deep-sequencing using case-control studies in pediatric atopy.

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